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Genistein, min. 98 %, for biochemistry, Molar mass (M) 270,24 g/mol, Storage temp. +4 °C, CAS No. 446-72-0, EC No. 207-174-9, Empirical formula C15H10O5
Competitive inhibitor of ATP binding to the catalytic domain of tyrosin kinases. Exceptional are the insulin receptor tyrosin kinase and the serin-/threonin specific proteases, which will not be inhibited by genistein. An additional, tyrosin kinase independent, effect of genistein is the inhibition of topoisomerases I and II.
Working concentration: 10-100 µM
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